Manal Abdel-kareem Ayyash

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Research

Tableting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual comp

Authors : A Aljaberi, A Ardakani, A Khdair, SA Abdel-Rahim, E Meqdadi, M Ayyash

Abstract : Prosolv Easytab is a recently introduced all-in-one excipient for direct compression. The aim of this work was to compare the compaction and dissolution functionalities of Prosolv Easytab versus equivalent physical mixtures of microcrystalline cellulose (MCC) or silicified microcrystalline cellulose (Prosolv SMCC) with complementary excipients. Lutrol F68 was used as a free flowing and poorly compactable model material for the comparison of the compaction functionality, and carbamazepine was used as a poorly soluble model drug for the investigation of the dissolution rate and dissolution stability after storage under accelerated stability conditions. Results showed that Prosolv Easytab produced comparable compactibility, dissolution and dissolution stability to its analogous physical mixtures based on MCC or Prosolv SMCC. The current findings suggest that Prosolv Easytab is functionally equivalent to physical mixture of its components, with obvious advantages regarding simplicity of manufacture and the potential masking of undesirable properties of individual components.

Keywords : Prosolv Easytab – Prosolv SMCC – Microcrystalline cellulose – Silicified microcrystalline cellulose – Co-processed excipients – Compactibility

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Occupational exposure of pharmaceutical workers to drug actives and excipients and their effect on Staphylococcus spp. nasal carriage and antibiotic resistance

Authors : RN Haddadin, SA Saleh, MA Ayyash, PJ Collier

Abstract : Background: Pharmaceutical manufacturing workers are exposed to significant amounts of product ingredients, including antibiotics. Such exposure could affect their nasal microflora. Objective: To assess the effect of exposure to various unidentified pharmaceutical ingredients in cephalosporin-manufacturing and non-cephalosporin plants on the nasal carriage of Staphylococcus spp. and their antibiotic resistance. Methods: Nasal swab samples were collected from 39 workers in both plants on three different occasions. Staphylococci were isolated and identified to genus level. Antibiotic resistance profiles were determined and subsequent identification to species level was performed. Results: There was complete absence of S. aureus in the samples collected from workers in both facilities. Multiple drug resistant

Keywords : Coagulase negative, staphylococci, Multiple drug, resistance, Pharmaceutical, workers

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Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions

Authors : M Ayyash, AA Shehabi, NN Mahmoud, AG Al-Bakri

Abstract : Aims To investigate the efficiency of triclosan, ethylenediaminetetraacetic acid (EDTA) and cranberry alone or in combinations against Escherichia coli strains as urinary catheter lock solutions to reduce catheter-associated urinary tract infections. Methods and Results Viable counting was used to assess antibiofilm activities for triclosan, EDTA and cranberry alone or in combinations against E. coli strains embedded in biofilm onto all-silicon Foley catheter surface. The results revealed that combination of triclosan (10 mg ml−1/EDTA 30 mg ml−1) when filling the catheter balloon was able to eradicate and prevent biofilm formation among all tested E. coli including the resistant strains, whereas triclosan (8·5 mg ml−1)/ cranberry (103 mg ml−1) combination was a successful catheter lock solution by preventing all tested strains from adhering onto catheter surface when filled via the eye hole. Conclusions The combinations of triclosan/EDTA and triclosan/cranberry were significantly effective in eradicating and preventing biofilm formation of the tested E. coli strains on Foley catheters. Significance and Impact of the Study Combinations of triclosan/EDTA and triclosan/cranberry have a promising application as nonantibiotic catheter

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Assessment of public knowledge and perception about the use of probiotics

Authors : M Ayyash, MAA Al-Najjar, K Jaber, L Ayyash, R Abu-Farha

Abstract : Introduction In Jordan, there is a remarkable lack of public awareness about probiotics and available guidance on their use. This study was designed to evaluate Jordanians’ awareness and perception about probiotics and their willingness to use these nutritional supplements as a part of their daily diet. Methods This cross-sectional survey was conducted among the Jordanian public. During the study period, participants were invited to fill out an electronic-based questionnaire. Results A total of 508 people agreed to participate in the study. Among them, 64.0% (n = 325) reported that they were willing to take probiotics. Only 17.1% of the surveyed participants (n = 90) knew that probiotics were not dead microorganisms. Only 55.0% of participants (n = 279) believed that probiotics were safe to consume. In addition, 75.0% (n = 381) believed that community pharmacists had a limited role in improving public knowledge about probiotics. Regression analysis showed that participants with higher income (>500 JD/month) and those who had medical degrees had greater knowledge about probiotics compared to others (P <0.001). Conclusion This study demonstrated that there is inadequate knowledge about probiotics and their potential use. More effort is needed to provide more information about the benefits of probiotics. Greater knowledge could be achieved by encouraging medical doctors and pharmacists to inform the public about probiotics.

Keywords : Probiotics, Knowledge, Perception , Jordan , Willingness

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Pharmacists' knowledge and perceptions regarding wound management at the community pharmacies in Jordan

Authors : Manal Ayyash1 , Kamel Jaber2 , Maram Abu Moghli3 , Tareq L Mukattash4

Abstract : Community pharmacists play an important role by being a valuable resource in the management of the wound. In this descriptive cross-sectional survey-based study conducted during October 2020, we aimed to assess community pharmacists’ knowledge and perception regarding wound management at the community pharmacies in Jordan. Thus, community pharmacists in Jordan have been invited to fill out an electronic-based survey. During the study period, 152 community pharmacists participated in this study. Regarding participants’ knowledge about wound management, pharmacists showed good knowledge regarding the medications and conditions known to delay wound healing. On the other hand, 82.2% reported a lack of adequate knowledge and adequate skills to deal with wounds. Finally, results showed that male pharmacists showed a higher knowledge score about wound management compared to females (p = 0.001). Those pharmacists who attended a course/workshop about wounds showed a significantly higher knowledge score than those who did not (p < 0.001). In conclusion, our findings revealed that awareness campaigns and educational workshops are needed to enhance

Keywords : Wound care, community pharmacy, knowledge, perception, pharmacists, Jordan

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Synthesis and Antibacterial Activity of Some Novel N, N-Di-Oxalamide Derivatives

Authors : M Habash, MY Mohammad, M Ayyash, MO Taha

Abstract : Novel N,N-di-oxalamide derivatives 1-6 were synthesized and characterized by the spectroscopic techniques. These derivatives showed good antibacterial activities against Gram-negative organism Escherichia coli and Gram-positive organisms Staphylococcus aureus and Bacillus subtilus. However, compounds 3 and 4 showed potent antibacterial activity against Gram-negative organism Escherichia coliand Gram-positive organism Staphylococcus aureus. In addition to that, we compared their antibacterial profiles with previously synthesized N,N-di-oxalamide derivatives 7-9. The new compounds showed superior antibacterial

Keywords : N,N-Di-oxalamide derivatives. Escherichia coli, Staphylococcus aureus, Bacillus subtilus, Antibacterial activity

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Perception and awareness of osteoporosis and its related risk factors among women: A cross-sectional study

Authors :Jaber, Rajaa Dagash, Rana Abu Farha and Eman EffishatName of authors

Abstract :Objectives: This study was designed to assess the awareness of women of the risk factors and ted sectional study that was conduc-preventive measures of osteoporosis. Methods: This is a cross in Jordan. During the study period, a convenience sample of women were invited to participate via a survey link communicated through social media. Linear regression was used to screen independent variables affecting participants’ awareness of osteoporosis, its risk factors, and eed to participate in this study, with a median age of preventive measures. Results: 426 women agr 38.5 years (IQR=16.0). Results showed that women have a median awareness score of 5.0 out of 9.0 (IQR=4.0) about osteoporosis risk factors, whereas women with higher educational levels (diploma related degrees have a higher awareness about osteoporosis risk -or higher) and those with medical factors compared to others (p≤0.05). Medical websites were the primary source used to obtain information about osteoporosis by the participating women (n=236, 55.4%). Also, results showed that more than 90% of the women believed that osteoporosis is a chronic silent disease that makes your bones less dense and more fragile (n=418, 98.1%), and that bone strength may increase by taking vitamin D and calcium (n=405, 95.0%). Conclusion: This study showed that women had an intermediate level of awareness of osteoporosis and prevention measures. The importance of medical websites and social media as sources of information was also demonstrated. More public targeted campaigns are needed to promote awareness of osteoporosis, its risk factors, prevention, and treatment.

Keywords : awareness, perception, women, Jordan Keywords

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Research Title :Exploring the antimicrobial potential of pomegranate peel extracts (PPEs): Extraction techniques and bacterial susceptibility

Authors :Reem Fawaz Abutayeh, Manal Ayyash, Ruaa A. Alwany, Alaa Abuodeh, Kamel Jaber and Mohammad A. A. Al-Najjar

Abstract :Antimicrobial resistance is increasing globally and is one of the major public health concerns. This highlights the need to search for new antimicrobial agents. Natural fruit by-products are a rich source of bioactive compounds. Pomegranate (Punica granatum) fruit is particularly rich in phenolic bioactive phytochemicals. These compounds are known for their antioxidant, anti-inflammatory, and anticancer properties. Furthermore, they exhibit a broad spectrum of antimicrobial effects. Bioactive phytochemicals are found mainly in peel (exocarp and mesocarp), which constitute about 50% of the whole fresh fruit. This study utilized pomegranate of Jordanian origin to evaluate the antimicrobial activity of different Pomegranate peel extracts (PPEs) alone and/or in combination with antibacterial agents against four bacterial strains. Different solvents and extraction methods were employed to obtain the PPEs. A key focus was to explore the enhancement of antibacterial activity against gentamicin-resistant Pseudomonas aeruginosa (P. aeruginosa) when microwaved aqueous extracts are combined with gentamicin. The antibacterial activity of PPEs varied depending on the extraction method and the solvent used. Notably, the aqueous macerate and microwave-assisted extract showed high potency and similar activity against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and P. aeruginosa (MICs 12.5, 25, and 25 μg/μL, respectively for both aqueous extracts). In contrast, Proteus mirabilis (P. mirabilis) was more susceptible to the inhibitory activity of organic PPEs with a MIC of 25 μg/μL recorded with the use of ethanolic solvents. Bacterial antagonistic activity was observed against gentamicin-resistant P. aeruginosa, particularly when lower concentrations (3.125, 1.562, 0.781, and 0.39 μg/μL) of microwaved aqueous PPEs were evaluated in combination with different concentrations of gentamicin. In conclusion, pomegranate peels, a natural and safe by-product, demonstrate promising antimicrobial potential. Furthermore, combining PPEs with conventional antibiotics shows promise in addressing antibiotic resistance, highlighting their potential role in treating infectious diseases.

Keywords : Antimicrobial, pomegranate peel extracts , bacterial susceptibility, Extraction techniques

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Research Title :Evaluating women’s knowledge about dietary supplement use during pregnancy

Authors :Aya Dagash, Rajaa Dagash, Ala Abu-Odeh, Leen Fino, Manal Ayyash, Beisan Ali Mohammad

Abstract :Purpose Dietary supplements are important in improving maternal health and birth outcomes during pregnancy. This study aims to assess women’s knowledge about the benefits, sources and proper intake of dietary supplements during pregnancy. Design/methodology/approach This cross-sectional study was conducted among women at Jordan University Hospital in Amman, Jordan from July to October 2023. Findings A total of 448 women completed the questionnaire. Analysis of the results showed that among all questions, participants perceived sufficient knowledge about dietary supplements' beneficial effects. Around 50% of the participants did not recognize the importance of vitamin B12 and vitamin A. Most participants identified that iron supplements should not be taken with dairy products, coffee, tea, calcium and antacids. Most participants did not know the source of vitamin A (82.1%), and only 44% knew the correct source of vitamin B12. Less than half of the participants recognized the appropriate administration time for each dietary supplement. Originality/value The knowledge level of the interaction between iron and food, natural sources of vitamins and their benefits was high, less than half of the participants showed poor knowledge about the proper time to take the dietary supplement. Patient education and counseling is important to improve health outcomes.

Keywords :Pregnancy, Minerals, Vitamins

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Research Title :Patterns of Antibiotic Use, Knowledge, and Perceptions among Jordanian Population: A Cross-sectional Study

Authors : Manal Ayyash, Rana Abu Farha, Kamel Jaber, Suleiman Ateih, Amal Akour

Abstract :Background: Practices concerning antibiotic use have detrimental impacts on body immunity, bacterial resistance, and the overall health of the general population. Misconceptions regarding antibiotic use can lead to improper use and malpractice, posing numerous health threats. Objectives: This study aims to assess the knowledge, practices, and awareness of Jordanian adults about antibiotics. This includes an analysis of their understanding of antibiotic uses and the sources from which they acquire such knowledge. Methods: A representative sample of Jordanian adults was invited to participate in an online survey distributed through social media platforms. Key findings: The results showed that 77.6% of the participants had received an antibiotic at least once in the past 12 months. About two thirds reported no problems with using a different brand name (alternative) for the prescribed antibiotic. The majority of respondents trust the decisions made by pharmacists. Moreover, participants with higher ages, female participants, those with a higher level of education, uninsured participants, and those with a medicine-related degree showed better antibiotic knowledge compared to others (P<0.05 for all). Conclusion: There is a good level of antibiotic-related knowledge amongst Jordanian adults. However, prevalent misconceptions and improper use also exist, indicating the need for focused attention on correcting such practices that might adversely impact the health of the community as a whole

Keywords : Awareness, perception, antibiotics, Use, Jordan

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Research Title :Skin-lightening products and Jordanian women: Beliefs and practice. A cross-sectional study

Authors :Manal Ayyash , Kamel Jaber, Razan I. Nassar, Leen Fino, Lana Mango, Alaa Abuodeh

Abstract :Background The use of skin-lightening products (SLPs) among Jordanian women has immensely increased and healthcare professionals have a vital role in raising public awareness of SLPs. The aim of this study is to identify SLPs practices among Jordanian women and their basic knowledge of the agents and the side effects associated with using these products. Methods A cross-sectional study conducted during October to December of 2022. Jordanian women above 18 years of age were invited to participate via a survey link. Descriptive statistics were used, and logistic regression was applied to screen for variables affecting the knowledge score of the participants. Results The mean age of the study participants (n = 384) was 32.04 (SD = 12.678). Results demonstrated that more than half of the participants (n = 193) reported current or past use of SLPs. Additionally, less than one-fifth (18.2%) of the participants (n = 70) reported previously experiencing some side-effects after using SLPs. About 90% of participants thought that these side-effects were caused by the active ingredients in SLPs. Most of the participants were able to identify some of the active ingredients used in SLPs such as Vitamin C (87.8%) and Hydroquinone (62.0%). It was also found that young participants, and those employed, or university students had higher knowledge scores of SLPs’ active ingredients, and of their side-effects. Conclusion This study demonstrated that Jordanian women are adequately informed about skin-lightening products. Moreover, the practices revealed an educated pattern of action when obtaining information regarding SLPs. Fundamentally, healthcare providers should be influential in educating consumers on the proper use. Strict guidelines and policies should target the practices concerned with these products

Keywords : Skin lighting, Jordan, Women, pracice

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M.Sc. Manal Abdel-kareem Ayyash

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