Morning Salivary Cortisol Associates with Elevated Serum Leptin Levels in Jordanian Young Men with Olive Pollen Induced Allergic Rhinitis
Authors : Mahmoud Abu-Samak , Ahmad Abu-Zaiton , Ahmad Al-Jaberi , Ahmad Sundookah, Omar Atrooz , Khalid M. Abu khadra6, Rula Kuzaie and Wamidh H. Talib
Abstract : Aims: Recent studies have shown independently inter-correlations between allergy, obesity, leptin hormone, and stress markers. However, these findings were unclear and contradictory. Thus the aim of the present study is to evaluate diurnal levels of salivary cortisol and DHEA in sample of Jordanian young men with history of olive pollen-induced Original Research Article British Journal of Medicine & Medical Research, 4(3): 797-806, 2014 798 allergic rhinitis in relation to serum levels of leptin. Methodology: 130 university male students aged (21.98±1.78) years, were divided into two groups (59 allergic and 71 non allergic). Fasting blood samples were collected and tested for blood glucose, lipid profile, serum leptin, and salivary stress hormones (cortisol and DHEA). Results: Allergic subjects showed significantly higher means of serum leptin (p
Keywords : Allergy; stress; obesity; salivary cortisol; DHEA; leptin; lipid; Jordanian
Visit
The Equivalence Of Online Tests Verses Paper-Pencil Tests: A Study On Undergraduate Students At Applied Science Private University
Authors : khuzaie R. F1 , Tala H. sasa1 , Tasneem. I. Al Ayed1 , Amane Istaiti1 , Noha Alzubaidi2
Abstract : Approximately all universities in Jordan now administer online exams. The results of these tests feed into accountability systems. We examine the degree of satisfaction for online testing. Crucial to the study design is the fact that the university students vary in the level of education, age, Faculties and GPA. In most cases of our study, we find that students in favor of online exam. They find the online exam suitable for all stages, easier than paper-pencil tests, they prefer circulating online exams instead of paperpencil tests, time required to perform online exams is less than that for paper-pencil tests, and hence, preferable for future testing. There was somewhat less consistency in reliability of online exams compared to paper-pencil tests, participants find that online exams don’t reflect true level of examiners, suitability for all subjects. Participants find online exams have many disadvantages and increase stress of examiners.
Keywords : Online exam, computer based exam, paper pencil exam, ASU exam, GPA, level of education, faculties, students
Visit
Lipid and hematological parameters in hyperleptinemic healthy Arab male youth in Jordan
Authors : Mahmoud Abu-Samak , Al-Motassem Yousef, Ahmad Al-Jarie, Hisham Y Al-Matubsi, Ahmed Abu-Zaiton, Mamoun Al-Quraan, Rula Khuzaie
Abstract : To analyze the influence ofhyperleptinemia on fasting lipid and hematological parameters in healthy Arab male youth in Jordan, this cross-sectional study was carried out in April 2009 on a sample of 120 students aged 18-24 years. Subjects were stratified by fasting leptin into two groups (control, <12.7 ng mL(-1) vs. hyperleptenimic, e_< 12.7 ng mL(-1)) and BMI (normal weight, < 25 kgm(-2) vs. overweight/obese, BMI e_< 25 kg m(-2)). Fasting serum leptin, blood glucose, lipid profile and hematological parameters values were determined by standard kit methods. Mean serum leptin concentrations were more than five times as high in hyperleptenemic subjects than in control subjects (p < 0.001). Compared with control group, significant elevations (p < 0.01) were observed in the means total cholesterol, LDL cholesterol and triglyceride levels of hyperleptenemic group whereas no significant differences was detected in HDL-cholesterol. Except the changes of WBC count, MCH and slightly MCHC, there were no differences between both groups in any other term of hematological parameters. In conclusion, changes in lipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youth at risk for dyslipidemia and cardiovascular diseases. Thus, hyperleptinemia could be a useful index in identifying healthy youth male subjects but this hypothesis needs further investigation
Keywords : Lipid profile, hematological parameters
Visit
Association of parental history of type 2 diabetes mellitus with leptin levels in Jordanian male youths
Authors : Mohammad O Abu-Hasheesh , Mahmoud S Abu-Samak, Hisham Y Al-Matubsi, Malak S Jaradeh, Samiha S Jarrah, Rula F Khuzaie
Abstract : Objective: To investigate the association between high level serum leptin in male youths in relation to parental history of type 2 diabetes mellitus (T2DM) and body mass index (BMI). Methods: This cross-sectional study was carried out at the Department of Medical Technology, Applied Science University, Amman, Jordan during the period from January to April 2009. One hundred and sixteen Jordanian male nursing students aged 18-24 years were divided into 4 groups according to parental history of T2DM and BMI. Fasting blood samples were measured for blood glucose, lipid profile, and serum leptin. Results: Serum leptin levels in overweight and obese male youth diabetic patients with parental history of T2DM were significantly higher than in those overweight and obese without parental history (p<0.001). Of the 116 subjects, 83 (71.6%) had a positive parental history of T2DM. Compared with other groups, significant (p<0.001) elevation was observed in the mean cholesterol and triglyceride levels of obese T2DM. No significant differences were detected in high-density lipoprotein, low-density lipoprotein, and blood glucose levels among all study groups. Conclusion: High levels of leptin in overweight and obese Jordanian male youths were more likely associated with a positive parental family history of T2DM than BMI factor.
Keywords : Leptin, Jordanian male, diabetes mellitus type 2
Visit
Relationship of Vitamin B12 Deficiency with Overweight in Male Jordanian Youth
Authors : Mahmoud Abu-Samak, Rula Khuzaie, Mohamman Abu-Hasheesh, Jaradeh Malak
Abstract : The purpose of this research was to investigate the association between weights status, as measured by Body Mass Index (BMI) and vitamin B12 levels among male Jordanian youth. Recent studies have shown correlation between Body Mass Index (BMI) and serum vitamin B12 levels in some Middle East countries; however, no data are available for Jordan, where the prevalence of vitamin B12 deficiency has increased at an alarming rate. One hundred and twenty male university students (aged 18 to 24 years) from Amman city, Capital of Jordan, were divided into three groups according to the body mass index namely healthy weight, overweight and obese. Fasting samples were collected for hematological parameters, serum leptin, vitamin B12, folic acid and blood glucose. The mean serum vitamin B12 level was decreased in overweight students (283 . 2 ± 84 . 17) pg mL1 comparing with the mean of all groups (353.73 ± 125) pg mL1. Of all students 16 % had B12 deficiency ( < 200 pg mL1) and 65 % of them were overweight. Serum folate levels were normal in all groups. BMI was positively correlated with serum leptin levels in all groups. Significant elevation was observed of white blood cells count in obese group (p < 0.001). Present findings suggest that overweight youth are a risk group for vitamin B12 deficiency.
Keywords : Vitamin B12, overweight
Visit
Melanocyte-Stimulating Hormone Modulates Blood Viscosity in Short-Term Alloxan-Induced Diabetic Rats
Authors : Mahmoud Abu-Samak, Rula Khuzaie , Moayad Khataibeh and Fahmi Mahmoud
Abstract : The effects of MSH on whole blood viscosity (WBV)and hematocrit (Ht) levels in short-term alloxan-induced diabetic were studied. Male and Female Sprague-Dawley diabetic rats weighing 185-250 g were given intraperitonially (i.p.) a daily injection of 20 mg alloxan solution/100 g of body weight for 10 days. Normal and diabetic rats were given daily injection (i.p.) of alpha-Melanocyte stimulating hormone (MSH) at a dose of 2 μg/100 g b.w for 10 days. Body weight, serum glucose, serum insulin, Ht and WBV were measured. The results indicated that MSH decreased serum glucose levels in diabetic rats in comparison with normal rats. Our study demonstrates that MSH administration significantly lowers blood viscosity of short-term diabetic rats. It proposed that MSH may exert a protective effect on the vascular endothelial cells.
Keywords : MSH, blood viscosity, type-2 diabetic rats
Visit
Anti-complementary activity of several dimethyltin carboxylates and dimethyltin dichloride complexes with various donor ligands
Authors : R.F. Khuzaie, Luay Rashan, T.A.K. Al-Allaf
Abstract : The anti-complementary activities have been evaluated in vitro (using a test that detects complement proteins inhibition) for several dimethyltin carboxylates of the general formula Me2SnX2 [X = 1/2O2(CO)2 (oxalate), 1/2O2(CO)2CH2 (malonate), 1/2O2(CO)2CH=CH (maleate), 1/2O2(CO)2 C -CH2CH2CH2 (cyclobutyl dicarboxylate), O(CO)C6H11 (cyclobutyl carboxylate) and O(CO)CMe3 (pivolate)] and dimethyltin dichloride complexes of the general formula Me2SnCl2·L [L = 8-hydroxy quinoline (L1), 8-hydroxy quinoline-N-oxide (L2), 2,6-diaminopyridine (L3), cyclohexyl amine (L4), (1R, 2R)- 1,2-cyclohexane diamine (L5), 3,5-dimethylpyrazole (L6), harmaline (L7) and harmine (L8)]. The results obtained have been compared with those of the three known anticancer drugs (cisplatin, carboplatin and oxaliplatin) and with that of the starting material Me2SnCl2. Three of the tin compounds displayed remarkable anti-complementary activities (IC50 ≤ 0.1 μg mL-1) which are almost similar to those of the drugs and tenfolds better than that of Me2SnCl2 (IC50 = 1.0 μg mL-1)
Keywords : Anti-complementary, dimethyltin carboxalates
Visit