Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products
Authors : Wamidh H. Talib 1,*ORCID,Asma Ismail Mahmod 1,Sara Feras. Abuarab 1,Eliza Hasen 1,Amer A. Munaim 1,Shatha Khaled Haif 1,Amani Marwan Ayyash 1,Samar Khater 1,Intisar Hadi AL-Yasari 2 andLina T. Al Kury
Abstract : Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.
Keywords : hyperglycemia; cancer; Warburg effect; alternative therapies; obesity; metabolic syndrome; hyperinsulinemia; cancer metabolism; oxidative stress; natural products
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Chemoprevention effect of the Mediterranean diet on colorectal cancer: Current studies and future prospects
Authors : Asma Ismail Mahmod1, Shatha Khaled Haif2, Ayah Kamal1, Israa A. Al-ataby1 and Wamidh H. Talib1*
Abstract : Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer worldwide. Nevertheless, more than 70% of CRC cases are resulted from sporadic tumorigenesis and are not inherited. Since adenoma-carcinoma development is a slow process and may take up to 20 years, diet-based chemoprevention could be an effective approach in sporadic CRC. The Mediterranean diet is an example of a healthy diet pattern that consists of a combination of nutraceuticals that prevent several chronic diseases and cancer. Many epidemiological studies have shown the correlation between adherence to the Mediterranean diet and low incidence of CRC. The goal of this review is to shed the light on the anti-inflammatory and anti-colorectal cancer potentials of the natural bioactive compounds derived from the main foods in the Mediterranean diet.
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