Tableting functionality evaluation of Prosolv Easytab in comparison to physical mixtures of its individual comp
Authors : A Aljaberi, A Ardakani, A Khdair, SA Abdel-Rahim, E Meqdadi, M Ayyash
Abstract : Prosolv Easytab is a recently introduced all-in-one excipient for direct compression. The aim of this work was to compare the compaction and dissolution functionalities of Prosolv Easytab versus equivalent physical mixtures of microcrystalline cellulose (MCC) or silicified microcrystalline cellulose (Prosolv SMCC) with complementary excipients. Lutrol F68 was used as a free flowing and poorly compactable model material for the comparison of the compaction functionality, and carbamazepine was used as a poorly soluble model drug for the investigation of the dissolution rate and dissolution stability after storage under accelerated stability conditions. Results showed that Prosolv Easytab produced comparable compactibility, dissolution and dissolution stability to its analogous physical mixtures based on MCC or Prosolv SMCC. The current findings suggest that Prosolv Easytab is functionally equivalent to physical mixture of its components, with obvious advantages regarding simplicity of manufacture and the potential masking of undesirable properties of individual components.
Keywords : Prosolv Easytab – Prosolv SMCC – Microcrystalline cellulose – Silicified microcrystalline cellulose – Co-processed excipients – Compactibility
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Occupational exposure of pharmaceutical workers to drug actives and excipients and their effect on Staphylococcus spp. nasal carriage and antibiotic resistance
Authors : RN Haddadin, SA Saleh, MA Ayyash, PJ Collier
Abstract : Background: Pharmaceutical manufacturing workers are exposed to significant amounts of product ingredients, including antibiotics. Such exposure could affect their nasal microflora. Objective: To assess the effect of exposure to various unidentified pharmaceutical ingredients in cephalosporin-manufacturing and non-cephalosporin plants on the nasal carriage of Staphylococcus spp. and their antibiotic resistance. Methods: Nasal swab samples were collected from 39 workers in both plants on three different occasions. Staphylococci were isolated and identified to genus level. Antibiotic resistance profiles were determined and subsequent identification to species level was performed. Results: There was complete absence of S. aureus in the samples collected from workers in both facilities. Multiple drug resistant
Keywords : Coagulase negative, staphylococci, Multiple drug, resistance, Pharmaceutical, workers
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Antibiofilm properties of triclosan with EDTA or cranberry as Foley Catheter lock solutions
Authors : M Ayyash, AA Shehabi, NN Mahmoud, AG Al-Bakri
Abstract : Aims To investigate the efficiency of triclosan, ethylenediaminetetraacetic acid (EDTA) and cranberry alone or in combinations against Escherichia coli strains as urinary catheter lock solutions to reduce catheter-associated urinary tract infections. Methods and Results Viable counting was used to assess antibiofilm activities for triclosan, EDTA and cranberry alone or in combinations against E. coli strains embedded in biofilm onto all-silicon Foley catheter surface. The results revealed that combination of triclosan (10 mg ml−1/EDTA 30 mg ml−1) when filling the catheter balloon was able to eradicate and prevent biofilm formation among all tested E. coli including the resistant strains, whereas triclosan (8·5 mg ml−1)/ cranberry (103 mg ml−1) combination was a successful catheter lock solution by preventing all tested strains from adhering onto catheter surface when filled via the eye hole. Conclusions The combinations of triclosan/EDTA and triclosan/cranberry were significantly effective in eradicating and preventing biofilm formation of the tested E. coli strains on Foley catheters. Significance and Impact of the Study Combinations of triclosan/EDTA and triclosan/cranberry have a promising application as nonantibiotic catheter
Keywords :
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Assessment of public knowledge and perception about the use of probiotics
Authors : M Ayyash, MAA Al-Najjar, K Jaber, L Ayyash, R Abu-Farha
Abstract : Introduction In Jordan, there is a remarkable lack of public awareness about probiotics and available guidance on their use. This study was designed to evaluate Jordanians’ awareness and perception about probiotics and their willingness to use these nutritional supplements as a part of their daily diet. Methods This cross-sectional survey was conducted among the Jordanian public. During the study period, participants were invited to fill out an electronic-based questionnaire. Results A total of 508 people agreed to participate in the study. Among them, 64.0% (n = 325) reported that they were willing to take probiotics. Only 17.1% of the surveyed participants (n = 90) knew that probiotics were not dead microorganisms. Only 55.0% of participants (n = 279) believed that probiotics were safe to consume. In addition, 75.0% (n = 381) believed that community pharmacists had a limited role in improving public knowledge about probiotics. Regression analysis showed that participants with higher income (>500 JD/month) and those who had medical degrees had greater knowledge about probiotics compared to others (P <0.001). Conclusion This study demonstrated that there is inadequate knowledge about probiotics and their potential use. More effort is needed to provide more information about the benefits of probiotics. Greater knowledge could be achieved by encouraging medical doctors and pharmacists to inform the public about probiotics
Keywords : Probiotics, Knowledge, Perception , Jordan , Willingness
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Pharmacists' knowledge and perceptions regarding wound management at the community pharmacies in Jordan
Authors : Manal Ayyash1 , Kamel Jaber2 , Maram Abu Moghli3 , Tareq L Mukattash4
Abstract : Community pharmacists play an important role by being a valuable resource in the management of the wound. In this descriptive cross-sectional survey-based study conducted during October 2020, we aimed to assess community pharmacists’ knowledge and perception regarding wound management at the community pharmacies in Jordan. Thus, community pharmacists in Jordan have been invited to fill out an electronic-based survey. During the study period, 152 community pharmacists participated in this study. Regarding participants’ knowledge about wound management, pharmacists showed good knowledge regarding the medications and conditions known to delay wound healing. On the other hand, 82.2% reported a lack of adequate knowledge and adequate skills to deal with wounds. Finally, results showed that male pharmacists showed a higher knowledge score about wound management compared to females (p = 0.001). Those pharmacists who attended a course/workshop about wounds showed a significantly higher knowledge score than those who did not (p < 0.001). In conclusion, our findings revealed that awareness campaigns and educational workshops are needed to enhance
Keywords : Wound care, community pharmacy, knowledge, perception, pharmacists, Jordan
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Synthesis and Antibacterial Activity of Some Novel N, N-Di-Oxalamide Derivatives
Authors : M Habash, MY Mohammad, M Ayyash, MO Taha
Abstract : Novel N,N-di-oxalamide derivatives 1-6 were synthesized and characterized by the spectroscopic techniques. These derivatives showed good antibacterial activities against Gram-negative organism Escherichia coli and Gram-positive organisms Staphylococcus aureus and Bacillus subtilus. However, compounds 3 and 4 showed potent antibacterial activity against Gram-negative organism Escherichia coliand Gram-positive organism Staphylococcus aureus. In addition to that, we compared their antibacterial profiles with previously synthesized N,N-di-oxalamide derivatives 7-9. The new compounds showed superior antibacterial
Keywords : N,N-Di-oxalamide derivatives. Escherichia coli, Staphylococcus aureus, Bacillus subtilus, Antibacterial activity
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